AT WHAT COST

At What Cost

Humans have long been considered the biggest threat to themselves. This doesn’t just refer to physical conflict and the many wars fought over the last century, but also our ability to spread bacteria, viruses, parasites, and fungi. With a rapidly increasing population, infectious diseases are continuing to be a large problem worldwide. “As the first infectious disease to emerge as a new cause of human illness in the 21st century, SARS underscores the growing importance of health issues in a globalized world” (Monaghan, 2004). Severe acute respiratory syndrome (more commonly known as SARS) is an atypical pneumonia caused by a virus that spread to over 8000 people across the globe when it surfaced in the early 2000’s. While SARS is not currently an immediate threat, it is worth discussing as the potential for resurging exists and it is a highly infectious disease.

While there is a lull in the havoc this disease causes, it is important to consider what actions should be taken if it resurfaces. Patients infected with SARS, as well as their families and others suspected to be at risk, should be quarantined. Beijing attempted this strategy when SARS originally surfaced by closing schools and forcibly locking both patients and healthcare workers in hospitals during the peak of the infections. While I believe that is an extremely inappropriate response, there are good arguments to be made in favour of quarantining individuals. First, it is important to understand that “isolation” refers to the separation of infected, symptomatic individuals, while “quarantine” refers to the separation of individuals who have been exposed to the infection, but are not yet ill. SARS has a four to six day incubation period. This means patients may have the disease for almost a week before they begin experiencing any symptoms. This, combined with the 10% mortality rate and spread via the droplet route, provide a strong case for quarantining individuals exposed to the deadly disease.

The two biggest counter arguments against quarantine are the potential cost, especially in a country that largely subsidizes medical treatment, and the ethical dilemma involving human rights. At first glance, it seems obvious that an extreme financial burden would be created by quarantining individuals just because they may have been exposed to an infectious disease like SARS. That being said, studies have already put this myth to rest. In a study presented in the Journal of Infection the “results indicate that quarantine is not only effective at containing newly emerging infectious diseases, but is also cost saving when compared to not implementing a widespread containment mechanism” (Gupta et al., 2005). A more compelling argument against quarantine is that it imposes on the right to freedom of movement. Is it acceptable for the government to place an asymptomatic individual in quarantine because a co-worker they have been working closely with or a family member has a confirmed infectious disease? After the AIDS epidemic in the 1980’s, the Siracusa principles were created to help determine when restriction to human rights can be justified. To summarize these principles, quarantine will be done in the best interest of the public, in accordance with the law, and without discrimination or unjustly restriction. It is worth considering that while quarantine may seem like a violation of the rights of the quarantined individual, letting them potentially spread a deadly disease they have been exposed to infringes on the rights of the rest of the population that they come into contact with. Sometimes small financial sacrifices or ensuring potentially infected individuals do something they may not want to must be done for the greater good.

All this information may initially be overwhelming, but lets look at what can be done in order to ensure our country doesn’t face another large scale SARS outbreak. First, there are many low-cost infection control changes that can be implemented. These can include the installation of Plexiglas shields at triage, increased hand sanitizer stations, and signage regarding respiratory hygiene and hand washing. These low cost implementations are not only beneficial for SARS, but for many other infectious diseases as well. Next, quarantine zones should be implemented for those exposed to the illness. This should be done in accordance with the Siracusa principles previously mentioned to minimize restriction on human rights. Lastly, financial support should continue to be given to those who require quarantine. As studies have already proven that quarantine is cheaper in the long-run, the government should have no issues in justifying the financial assistance of those requiring quarantine.

In conclusion, SARS is one of many extremely infectious diseases. Individuals suspected of being at risk should be quarantined for the greater good of quickly preventing the disease from the carnage it is capable of. This should be done in a way that makes sense financially and also minimizes restriction on human rights. Maybe the next time there is an outbreak of a deadly disease like SARS, the casualty count will be much lower.

To hear how Hong Kong has been changed, watch this video: Ten years on, the SARS outbreak that changed HK

RESCUE

Barbisch, D., Koenig, K.L., Shih, F.-Y., 2015. Is There a Case for Quarantine? Perspectives from SARS to Ebola. Disaster Medicine and Public Health Preparedness 9, 547–553. https://doi.org/10.1017/dmp.2015.38

Gupta, A.G., Moyer, C.A., Stern, D.T., 2005. The economic impact of quarantine: SARS in Toronto as a case study. Journal of Infection 50, 386–393. https://doi.org/10.1016/j.jinf.2004.08.006

Lander, F., er, 2014. Human rights and Ebola: the issue of quarantine | Global Health. Translational Global Health.

Martin, E., 2015. SARS, in: Concise Medical Dictionary. Oxford University Press.

Monaghan, K.J., 2004. SARS: DOWN BUT STILL A THREAT. National Academies Press (US).

SARS, questions and answers, 2003. Ontario. Ministry of Health and Long-Term Care.

OUR DRUGS FIX EVERYTHING

Our Drugs Fix Everything

Picture this. It’s late at night and you’re stressed out. Maybe you’re having difficulty sleeping or maybe your sexual performance isn’t what it used to be. You turn on the television to pass some time and there it is. A commercial is showing you the answer to all your problems! Your situation is about to change for the better… or is it? Lunesta® and Viagra® are just a couple of examples of companies that practice direct-to-consumer advertising. More examples can be found HERE (sorry for the poor quality).

Direct-to-consumer pharmaceutical advertising (DTCPA) can be defined as “an effort… made by a pharmaceutical company to promote its prescription product directly to patients” (Ventola, 2011). This is commonly practiced in the United States of America and New Zealand, but is currently prohibited in Canada. This generates a problem for Canadians because American-made television and North American edition magazines, that are created in the USA with DTCPA, can both be consumed by the Canadian population. Further, in the examples given above, the companies attempting to sell their product are biased. They are selling you a product that directly affects your health, but as a business, their main goal is to make profit. How do you, the consumer, know which advertisements you can trust when trying to optimize your health. The controversies surrounding DTCPA make it an extremely important social issue.

Before we can make an informed decision on DTCPA, we must understand both sides of the debate. DTCPA drives up the price of prescription drugs as consumers become willing to spend more money for brand name drugs. This also results in in pharmaceutical companies putting large amounts of money into advertising that would otherwise go into research. Doctors have also been proven more likely to prescribe a drug when a patiently specifically requested it (“Direct-to-consumer Advertising,” 2011). Not only does this increase the likelihood of a patient receiving less suitable medication, but DTCPA also encourages healthy patients to think they would be better off with medication. Lastly, DTCPA generates a “focus on blockbuster and lifestyle drugs [that] excludes provision of information to traditionally ignored at-risk groups, such as pediatric patients, pregnant women, and orphan disease patients” (Liang and Mackey, 2011). At the end of the day, the pharmaceutical companies can make the most money by appealing to the masses, instead of catering to specific subpopulations.

If after that you’re thinking to yourself, “we need to protect ourselves against direct-to-consumer pharmaceutical advertising,” consider the following. “The number of regulatory actions taken by the FDA against companies marketing prescription drugs to consumers has fallen dramatically in recent years” (Donohue et al., 2007). Although many argue that this proves a fault with the FDA, it could also be suggestive of better compliance with pharmaceutical companies following FDA advertising regulations. Many individuals may not know that there is a problem or solution until viewing advertisements for different medications. DTCPA can spark important conversations between patients and clinicians or health care providers. This can result in a reduction of underdiagnosed and undertreated conditions as well as the encouragement of patient compliance (Ventola, 2011). Random surveys of the US public conducted in the late 90’s revealed that 20-25% of the respondents had seen advertisements for drugs they were currently taking. Of those, 33% said the ads made them more likely to take their medication (Mintzes, 2006). This means that DTCPA makes patients more likely to follow instructions given to them by a medical professional and it’s hard to interpret that in a negative light.

Personally, I am not in favour of direct-to-consumer pharmaceutical advertising. I strongly believe that important decisions, such as which medications a patient takes, should be made by a medical professional. I don’t like the idea of a doctor’s decision being swayed by a patient who specifically requests a drug. Doctors may feel that this will lead to better patient compliance, but it can actually result in the patient receiving less than premium care. Pharmaceutical companies are also less likely to state the risks while generating appealing advertisements. Vioxx (advertisement seen above) was withdrawn in 2004 after it was discovered to elevate the risk of heart attack and stroke (Tman, 2017). This drug used a celebrity figure (Dorothy Hamill) and a catchy slogan (“For everyday victories”), but undersold the risks of taking their drug. This advertisement encourages disease mongering as it suggests that the undiagnosed pain the consumer may be feeling can be cured with this “magic bullet” drug. As a result, the health of many individuals suffered based on these advertisements. At the end of the day, these pharmaceutical companies are businesses and their primary interest is not in patient well-being, but turning a strong profit. I am in support of Canada’s current decision to prohibit direct-to-consumer pharmaceutical advertisement and I hope this policy remains in place for the foreseeable future.

For an excellent video that further weighs the pros and cons on this issue, watch: How Americans got stuck with endless drug ads.

RESCUE

Direct-to-consumer Advertising: Canadian Federation of Nurses Unions Backgrounder [WWW Document], 2011. URL https://deslibris-ca.proxy.queensu.ca/ID/248608 (accessed 11.13.18).

Donohue, J.M., Cevasco, M., Rosenthal, M.B., 2007. A Decade of Direct-to-Consumer Advertising of Prescription Drugs. The New England Journal of Medicine; Boston 357, 673–81. http://dx.doi.org.proxy.queensu.ca/10.1056/NEJMsa070502

Liang, B.A., Mackey, T., 2011. Reforming direct-to-consumer advertising. Nature Biotechnology 29, 397–400. https://doi.org/10.1038/nbt.1865

Mintzes, B., 2006. Direct-to-Consumer Advertising of Prescription Drugs in Canada [WWW Document]. URL https://deslibris-ca.proxy.queensu.ca/ID/203599 (accessed 11.13.18).

Tman, Z., 2017. Here’s why direct-to-consumer drug ads need FDA oversight [WWW Document]. KevinMD.com. URL https://www.kevinmd.com/blog/2017/12/heres-direct-consumer-drug-ads-need-fda-oversight.html (accessed 11.13.18).

Ventola, C.L., 2011. Direct-to-Consumer Pharmaceutical Advertising. P T 36, 669–684.

WHO I AM

Who I am

The sixth version of the International Classification of Diseases (ICD 6) was published in 1949 and deemed that mental disorders were in fact classified as diseases. This blanket statement encompasses all mental disorders, but are all mental disorders truly diseases? In this module we learned about “the disease concept,” and I plan on using this to identify one known mental disorder that should not be classified as a disease.

When I was a child, I was told that I had Attention Deficit Hyperactive Disorder (ADHD). This was the DIAGNOSIS given to me by a medical professional. Naming a disease allows them to group PATIENTS who suffer from similar ailments together. Until fairly recently, ADHD was considered a disorder affecting children that was outgrown by the end of adolescence and the beginning of adulthood. This is no longer the case as adults are not only exhibiting the same behaviors as when they were younger, but in fact being diagnosed over the age of 17. It has been diagnosed in roughly 3 times as many males as females giving it a more prevalent demographic. That being said, just because a condition has been given a name, and a group of people who it affects, doesn’t make it a disease.

A disease must have SYMPTOMS. In one Journal, symptoms of ADHD in adults include talkativeness, unable to make decisions, procrastinating, and being disorganized. This is a list of common personality traits, not an indication of a disease. Many people can have any or all of these personality traits without being considered as having ADHD just as many diagnosed individuals can have none of these. If I had heard only these symptoms, I might believe you are simply describing an extrovert or a teenager in their first year of university.

The problem with the proposed idea of ADHD is that there is no real test for it. As one Journal states, “ADHD is currently diagnosed by a diagnostic interview, mainly based on subjective reports from patients or teachers.” There is no concrete method of determining if an individual even has ADHD. If we can’t prove that they have it, maybe we can look at how they got it. The exact CAUSE of ADHD is unknown with speculations including genetics, behavioral, neurochemical, and even food. Without knowing how people develop ADHD there is no real way to prevent it.

If the test is subjective to determine if someone has ADHD and there is no way to prevent it, we should consider the OUTCOMES of those diagnosed (or misdiagnosed) with ADHD. Roughly 85% of the adult population who meet the criteria for ADHD go undiagnosed. They live their entire lives unaware that there may be a problem with them and are no worse for it in the context of their health. Some could argue that the previously mentioned symptoms of ADHD may not affect health, but may affect one’s ability to succeed in life. Diagnosed celebrities including comedian Howie Mandel, superstar Justin Timberlake, and Olympic record holder Michael Phelps would probably disagree.

Lastly, let’s consider the TREATMENT. While some believe ADHD symptoms can be treated with diet alone, the majority of the population look at using drugs in an aim to reduce symptoms. As we previously discussed, most of the symptoms are social traits and characteristics. Is being talkative necessarily a bad thing? This also brings up the ethical dilemma that changing an individual’s character traits can be seen as changing their personal identity.

When I was a younger, I was prescribed Ritalin to help manage my ADHD. Even though I was a child, my parents wanted to know how I felt about taking this medication. The doctor explained to me that Ritalin would “get rid of the excess noise and allow me to focus on the tasks at hand.” It was essentially explained to me that this drug would block some of my thoughts. Even at my early age, I was able to realize that there was no way for them to guarantee the thoughts being “blocked” wouldn’t be my best ides or my most creative inspirations. In my eyes, this is the way I am and how my brain operates. I am educated with a BSc in Math and Physics, I have friends and family that I love and whom love me, and I am completely infatuated with my work. There is no reason to believe that I am being negatively by the way that my brain is wired and potentially even benefit from it.

In conclusion, Attention Deficit Hyperactive Disorder is not in line with the Disease Concept, it does not necessarily have a negative impact on one’s quality of life, and therefore ADHD is not a disease.

For an interesting video on some of the science behind ADHD and how it can be beneficial watch: https://www.youtube.com/watch?v=n2EVEYmeSqg

RESCUE

Braganza, S.F., Galvez, M.P., Ozuah, P.O., 2006. When parents ask about diet therapy for ADHD: Part two. Contemporary Pediatrics 23, 47-.

Friedman, J., 2017. What is a disease? Rhode Island Medical Journal 100, 8–9.

Kyeong, S., Park, S., Cheon, K.-A., Jae-Jin, K., Dong-Ho, S., Kim, E., 2015. A New Approach to Investigate the Association between Brain Functional Connectivity and Disease Characteristics of Attention-Deficit/Hyperactivity Disorder: Topological Neuroimaging Data Analysis. PLoS One; San Francisco 10, e0137296. http://dx.doi.org.proxy.queensu.ca/10.1371/journal.pone.0137296

Shoot, B., 2011. The Stars Who Aligned ADHD with Success. ADDitude.

Valente, S., Kennedy, B.L., 2012. Recognizing and treating Adult ADHD: The Nurse Practitioner 37, 41–46. https://doi.org/10.1097/01.NPR.0000411105.20240.8c